This book addresses the problem of how to make democratically-legitimate public policy on issues of contentious bioethical debate. It focuses on ethical contests about research and their legitimate resolution, while addressing questions of political legitimacy. How should states make public policy on issues where there is ethical disagreement, not only about appropriate outcomes, but even what values are at stake? What constitutes justified, democratic policy in such conflicted domains? Case studies from Canada and Australia demonstrate that two countries sharing historical (...) and institutional characteristics can reach different policy responses. This book is of interest to policymakers, bioethicists, and philosophers, and will deepen our understanding of the interactions between large-scale socio-political forces and detailed policy problems in bioethics. (shrink)

Rule A: if it's metaphysically necessary that p, we may validly infer that no one is even partly morally responsible for the fact that p. Our principal aim in this article is to highlight the importance of this rule and to respond to two recent challenges to it. We argue that rule A is more important to contemporary theories of moral responsibility than has previously been recognized. We then consider two recent challenges to the rule and argue that neither challenge (...) successfully undermines the rule's initial appeal. (shrink)

Love's bitter fruits: Martha C. Nussbaum The Therapy of Desire: Theory and Practice in Hellenistic Ethics.Max Horkheimer, Between Philosophy and Social Science: Selected Early Writings.

More than 200 million children under the age of 5 years are affected by malnutrition worldwide according to the World Health Organization. The Barbados Nutrition Study (BNS) is a 55-year longitudinal study on a Barbadian cohort with histories of moderate to severe protein-energy malnutrition (PEM) limited to the first year of life and a healthy comparison group. Using quantitative electroencephalography (EEG), differences in brain function duringchildhood(lower alpha1 activity and higher theta, alpha2 and beta activity) have previously been highlighted between participants (...) who suffered from early PEM and controls. In order to determine whether similar differences persisted intoadulthood, our current study used recordings obtained during a Go-No-Go task in a subsample of the original BNS cohort [population size (N) = 53] at ages 45–51 years. We found that previously malnourished adults [sample size (n) = 24] had a higher rate of omission errors on the task relative to controls (n= 29). Evoked-Related Potentials (ERP) were significantly different in participants with histories of early PEM, who presented with lower N2 amplitudes. These findings are typically associated with impaired conflict monitoring and/or attention deficits and may therefore be linked to the attentional and executive function deficits that have been previously reported in this cohort in childhood and again in middle adulthood. (shrink)

Over the last twenty years, John Rawls has developed an approach to political philosophy which appeals to the notion of reflective equilibrium. This notion has proven suggestive to those attracted to coherence approaches to justification, in ethics and in other domains as well. In this paper, I explore the question whether Rawls’s approach provides a model for a coherentist account of justification, concluding that although the discussion of reflective equilibrium has provided helpful insights it has not produced a coherentist model (...) of justification. (shrink)

Previous research has shown that cognitive style impacts several areas of human behavior of interest to marketers. This article reports the results of an exploratory study testing the proposition that cognitive style can influence one's perceptions of what is and is not a matter of ethics. The findings indicate that cognitive style can play a role in one's perceptions of ethics, and may help further our understanding of the factors that bear on ethical points of view.

In his “Plantinga on Exclusivisim,” Richard Feldman argues that Alvin Plantinga, in an earlier paper, has not sufficiently addressed a particular problem for the religious exclusivist. The particular problem that Feldman thinks Plantinga has failed sufficiently to address is the problem of epistemic peer disagreement—that is, disagreement between two (or more) equally competent thinkers who share equally good reasons for, and are in equally good epistemic situations regarding, their contradictory beliefs—in matters of religious belief. To demonstrate that Plantinga has so (...) failed, Feldman introduces a principle, ‘B’, that purports to show that exclusivism (religious or not) tends to lead to unjustified beliefs. But I think that Feldman has failed successfully to show that B demonstrates exclusivism’s tendency to lead to unjustified beliefs; so, in the paper, I defend Plantinga, and the exclusivist more generally, from Feldman’s criticisms. (shrink)

The article is a review of A.P. Simester, ed., Appraising Strict Liability. We strongly recommend the book for the sophistication of the contributors’ analyses, and the contribution the book makes to clarifying the normative issues at stake in strict liability legal regimes. The review focuses on the more philosophical essays in the book. The specific issues from the book identified in the review are: the rights-based character of the prohibition on conviction without moral fault; the importance of the principle of (...) proportionality; due diligence defences; the instrumental worth of strict liability in relation to quasi-criminal regulation; the faultiness of genuinely creating risks. (shrink)

The modal version of the ontological argument (MOA) for God’s existence is controversial, primarily, at its first premise, the premise that reads “possibly, there exists a maximally great being.” So, what’s needed is an argument for the possibility of a maximally great being, a being that is omnipotent, omniscient, morally perfect, has these properties essentially, and is such that it exists necessarily. Ironically, I think that such an argument can be found in the literature on the problem of evil, literature (...) generally devoted to arguments against God’s existence. In particular, I argue that Alvin Plantinga’s “free will defense” (FWD) gives us such an argument. Moreover, since most philosophers agree that the FWD is successful, I argue that most philosophers should agree that FWD gives us a successful argument for the first premise of MOA. Thus, I argue that if most philosophers agree FWD is successful, then most philosophers should agree that God exists. There are several pressing objections to this line of reasoning that I consider in the paper. I argue that these objections fail. (shrink)

The so-called Direct Argument for the incompatibility of moral responsibility and causal determinism depends on a rule of inference called Rule A, a rule that says no one is even partly morally responsible for a necessary truth. While most philosophers think that Rule A is valid, Stephen Kearns has recently offered several alleged counterexamples to the rule. In the paper, I show that Kearns’ counterexamples are unsuccessful.

The cognitive science student deserves our sympathy. It is difficult to think of another area of study where there is so much disagreement amongst the constituent parts, and even within those parts themselves -- neuroscience, AI, philosophy, psychology, linguistics, quantum and evolutionary theory. To illustrate this difficulty for the erstwhile student, imagine cognitive science as a collection of ball games with mind/brain/ consciousness as the ball. Instead of being able to concentrate on the one game as one might expect to (...) in another subject, the student is faced with a disparate range of disciplines. Some participants maintain it is only they who are playing the real game and that other games should be assimilated to their own. Then there are theorists who like to borrow from a number of games to create their own, whilst others suggest there is no common ground at all between games. We could go on further with this part of the analogy but let us now focus on the ball. Notice how it changes shape, material, size and playing surface from one game to the next -- football, hockey, squash, golf, tennis. Yet at least here the balls are round, the surface solid. How about badminton, rugby and water polo? Hardly surprising then that a cognitive science student needs to have special skills to cope with this confusion. (shrink)

The period 800–200 B.C.E. has been called an axial period or age because it was a period of major technological and cultural change that led to the development of new worldviews, which in turn called for and led to the emergence of the current major world religious traditions. The world is now in the midst of another period of major global scientific, technological, and cultural change that is leading to the development of a new global worldview. In this worldview, the (...) cosmos is taken to be more like an activity than a thing—more like an emergent complex of interrelated and interactive doing in space–time than a created complex of beings in space and time–and its complexity and space—time scale are understood to be enormously greater than heretofore supposed.These changes in worldview call for changes in theology, religion, and ethics. Most workers in the field of science and religion are heeding this call by attempting to reconcile traditional religious concepts with the new scientific concepts. Others, however, have become convinced that the new worldview differs so radically from the previous ones as to mark a new axial age, which calls for a new, post‐traditional theology, religion, and ethics, with a theos that is more like an activator of doing than a ground of being, and with meaning and purpose achieved more by a quality of doing than a quantity or quality of being. (shrink)

(Report assembled for the Workshop of the AMIA Working Group on Formal Biomedical Knowledge Representation in connection with AMIA Symposium, Washington DC, 2005.) Best practices in ontology building for biomedicine have been frequently discussed in recent years. However there is a range of seemingly disparate views represented by experts in the field. These views not only reflect the different uses to which ontologies are put, but also the experiences and disciplinary background of these experts themselves. We asked six questions related (...) to biomedical ontologies to what we believe is a representative sample of ontologists in the biomedical field and came to a number conclusions which we believe can help provide an insight into the practical problems which ontology builders face today. (shrink)

Gil R, Arroyo-Anllo EM, Ingrand P, Gil M, Neau JP, Ornon C, Bonnaud V. Self-consciousness and Alzheimer’s disease. Acta Neurol Scand 2001: 104: 296–300. # Munksgaard 2001. Objectives – To propose a neuropsychological study of the various aspects of self-consciousness (SC) in Alzheimer’s disease. Methods – Forty-five patients with probable mild or moderate AD were included in the study. Severity of their dementia was assessed by the Mini Mental State (MMS). Fourteen questions were prepared to evaluate SC. Results – No (...) significant correlations were found between SC score and educational level, age, and duration of disease. A significant correlation was found between SC score and the severity of dementia, whereas frontal disturbances were just short of the significance threshold. The various aspects of SC were not impaired to the same degree. The most disturbed ones were awareness of cognitive deficiencies, moral judgements and prospective memory. The least disturbed aspects were awareness of identity and of mental representation of the body. Items relating to anosognosia and moral judgements were significantly correlated with the MMS score, whereas affective state, body representation disorders, prospective memory, and capacities for introspection were not related to the severity of the dementia. Consciousness of identity was sound, regardless of MMS score. Conclusions – AD clearly induces an heterogeneous impairment of SC. SC requires a convergence of many neural networks. In AD, neuronal alterations involve many cortical areas and information sent to the associative frontal cortex from memory, language and visuospatial areas is lacking or disturbed. Thus, the sequential order of successive stimuli cannot be maintained by the heteromodal associative cortex (dorsal convexity of the prefrontal cortex), and the supramodal associative cortex (located rostrally in the frontal lobes) is unable to provide reliable monitoring and assessment of simultaneous neural cognitive networks carrying insufficient and inadequate input. The core deficiency in AD patients might be impaired SC equated with the disability to maintain sequential and simultaneous ‘‘attention to life’’. The Self-Consciousness Questionnaire, a clinical scale providing multidimensional measurement, indicates that different aspects of consciousness are not correlated with overall cognitive deficiency as determined by the MMSE. (shrink)

In recent work, W. Matthews Grant challenges the common assumption that if humans have libertarian free will, and the moral responsibility it affords, then it is impossible for God to cause what humans freely do. He does this by offering a “non-competitivist” model that he calls the “Dual Sources” account of divine and human causation. Although we find Grant’s Dual Sources model to be the most compelling of models on offer for non-competitivism, we argue that it fails to circumvent a (...) theological version of Peter van Inwagen’s direct argument for incompatibilism. In the paper, we motivate and deploy a theological take on the direct argument, and we contend that this theological rendition of the direct argument effectively dismantles Grant’s Dual Sources account of non-competitivism. (shrink)

In his “Plantinga on Exclusivisim,” Richard Feldman argues that Alvin Plantinga, in an earlier paper, has not sufficiently addressed a particular problem for the religious exclusivist. The particular problem that Feldman thinks Plantinga has failed sufficiently to address is the problem of epistemic peer disagreement—that is, disagreement between two (or more) equally competent thinkers who share equally good reasons for, and are in equally good epistemic situations regarding, their contradictory beliefs—in matters of religious belief. To demonstrate that Plantinga has so (...) failed, Feldman introduces a principle, “B”, that purports to show that exclusivism (religious or not) tends to lead to unjustified beliefs. But I think that Feldman has failed successfully to show that B demonstrates exclusivism’s tendency to lead to unjustified beliefs; so, in the paper, I defend Plantinga, and the exclusivist more generally, from Feldman’s criticisms. (shrink)

In a recent paper, Seth Shabo sets out to show that logical renderings of the Direct Argument for incompatibilism about moral responsibility and causal determinism, an influential incompatibilist argument for this conclusion, fail. In particular, Shabo argues that the Direct Argument—cashed out in logical terms—fails because it rests on an invalid rule of inference, Rule B. Shabo argues that Rule B, rendered logically, is subject to a counterexample that he constructs. If he’s right about this, it follows that logical versions (...) of the Direct Argument fail. In the paper, I argue that Shabo’s alleged counterexample to Rule B is unsuccessful. Since Shabo’s counterexample fails, I conclude that he has failed successfully to undermine logical versions of the Direct Argument. (shrink)

Ensuring that life-saving antimicrobials remain available as effective treatment options in the face of rapidly rising levels of antimicrobial resistance will require a massive and coordinated global effort. Setting a collective direction for progress is the first step towards aligning global efforts on AMR. This process would be greatly accelerated by adopting a unifying global target — a well-defined global target that unites all countries and sectors. The proposed pandemic instrument — with its focus on prevention, preparedness and response — (...) represents an ideal opportunity to develop and adopt a unifying global target that catalyzes global action on AMR. We propose three key characteristics of a unifying global target for AMR that — if embedded within the pandemic preparedness instrument — could rally public support, funding, and political commitment commensurate with the scale of the AMR challenge. (shrink)

We report two experiments that investigated the widely held assumption that speakers use the addressee’s discourse model when choosing referring expressions (e.g., Ariel, 1990; Chafe, 1994; Givón, 1983; Prince, 1985), by manipulating whether the addressee could hear the immediately preceding linguistic context. Experiment 1 showed that speakers increased pronoun use (and decreased noun phrase use) when the referent was mentioned in the immediately preceding sentence compared to when it was not, even though the addressee did not hear the preceding sentence, (...) indicating that speakers used their own, privileged discourse model when choosing referring expressions. The same pattern of results was found in Experiment 2. Speakers produced more pronouns when the immediately preceding sentence mentioned the referent than when it mentioned a referential competitor, regardless of whether the sentence was shared with their addressee. Thus, we conclude that choice of referring expression is determined by the referent’s accessibility in the speaker’s own discourse model rather than the addressee’s. (shrink)

Methylation of DNA plays an important role in the control of gene expression in higher eukaryotes. This is largely achieved by the packaging of methylated DNA into chromatin structures that are inaccessible to transcription factors and other proteins. Methylation involves the addition of a methyl group to the 5‐position of the cytosine base in DNA, a reaction catalysed by a DNA (cytosine‐5) methyltransferase. This reaction occurs in nuclear replication foci where the chromatin structure is loosened for replication, thereby allowing access (...) to methyltransferases. Partly as a result of their recognising the presence of a methylcytosine on the parental strand following replication, these large enzymes are able to maintain the distribution of methyl groups along the DNA of somatic cells and, thereby, maintain tissue‐specific patterns of gene expression. (shrink)

Musicians generally believe that memory differs from one person to the next. As a result, memorizing strategies that could be useful to almost everyone are not widely taught. We describe how an 18-years old piano student (Grade 7, ABRSM), learned to memorize by recording her thoughts, a technique inspired by studies of how experienced soloists memorize. The student, who had previously ignored suggestions that she play from memory, decided to learn to memorize, selecting Schumann’s “Der Dichter Spricht” for this purpose. (...) Rather than explicitly teaching the student how to memorize, the teacher taught her to record her thoughts while playing by marking them on copies of the score, adapting an approach used previously in research with experienced performers. Over a 6½ week period, the student recorded her thoughts during practice (five times) and while performing from memory for the teacher (three times). The student also video-recorded 3 weeks of practice, three performances, and the reconstruction of the piece from memory after a 9½-weeks break. The thoughts that the student reported were prepared during practice, stable over time, and functioned as memory retrieval cues during reconstruction. This suggests that the student memorized in the same way as the more experienced musicians who have been studied previously and that teaching student musicians to record their thoughts may be an effective way to help them memorize. The speed and durability of her memorization surprised the student, inspiring her to perform in public and to use the same technique for new pieces. (shrink)

SummaryChristians often presume that immediate and universally extensive divine governance of human behavior is incompatible with human agency and responsibility. Against this presumption, Kathryn Tanner argues for a distinctive metalinguistic paradigm whereby Christians can coherently speak of God’s transcendence in such a way that divine action could never in principle ‘compete’ with human action. Thus, it is said, God can comprehensively will each human action without thereby compromising significant human freedom and corresponding moral responsibility. In this article, it is argued (...) that Tanner’s non-competitivist paradigm fails to circumvent a theological version of the ‘direct argument’ for the incompatibility between human moral responsibility and causal determinism. (shrink)

A number of philosophers and theologians have recently challenged the common assumption that it would be impossible for God to cause humans actions which are free in the libertarian or incompatibilist sense. Perhaps the most sophisticated version of this challenge is due to W. Matthews Grant. By offering a detailed account of divine causation, Grant argues that divine universal causation does not preclude humans from being ultimately responsible for their actions, nor free according to typical libertarian accounts. Here, we argue (...) that the kind of divine universal causation that Grant proposes is incompatible with a plausible interpretation of Robert Kane’s influential conception of ultimate responsibility. This conclusion is significant since Grant seeks to harmonize his divine causal account with Kane’s articulation of ultimate responsibility. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Roger A. Shiner GETTING TO KNOW YOU IN pursuits OF happiness, Stanley Cavell attempts to establish the existence of a previously unrecognized genre of film — "comedies of remarriage " — which both includes and is defined by such movies as Adam's Rib, Bringing Up Baby, and TL· Philadelphia Story. l By "marriage" and "remarriage " is meant a certain kind of enduring emotional intimacy with which we (...) as adult men and women will be involved, an intimacy which is an integral part of the human form of life and whose relationship to an institutionally supported legal status in our culture is not one of identity. The same is true for the concept of "divorce" in this context. Using some of Cavell's interpretive ideas as a starting point, I shall seek to present the genre of remarriage as a figure for the profoundest relationships of epistemology and metaphysics — the relationship of the knower to the world which is known and the relationship of the individual to die other individuals widi whom society is shared. Specifically, divorce and remarriage as part of human life are to be seen as figures for separation and kinship, avoidance and acknowledgement in the philosophical sense of those terms.2 My discussion proceeds on several levels. There is film criticism, which attempts to find significance in certain movies. There is an examination of values, which presents a certain view ofmarriage as a human relationship. There is some metaphysics, which addresses certain traditional philosophical problems in a nontraditional way. And finally there is metaphilosophy, which attempts to present a different way ofhow to ask, and how to acknowledge as being answered, the great questions of philosophy. Only the latter two projects could be described as "philosophical" in a conventional sense. Yet, as Arthur Danto has rightly remarked,3 Cavell in Pursuits ofHappiness seems to be trying to suggest that to blur deliberately the distinction between criticism and philosophy is to show something 80 Roger A. Shiner81 important about philosophy (and thus criticism as well). If this essay in some small way is thought to show something similar, I shall be pleased. Cavell begins his chapter on It Happened One Night with some ruminations on Locke, Hume, Kant, and the idea of the limitations of human reason. Kant undertakes to show, Cavell claims (PH, pp. 75-76), that our position as human knowers is both better and worse than the Empiricists suggest. It is worse, because even if we pressed human knowledge to its Kantian limits, we would know more but not enough to fulfill the philosopher 's dream. It is better, because the very facts that are limitations of human knowledge are also the necessary conditions ofknowledge as such and to know those conditions clearly is enormously to increase human knowledge. The link between the limitations ofhuman knowledge and the comedies of remarriage is forged by the thought (CR, p. 74) that the capacity to relate oneself to the world by knowledge and the capacity to relate oneselfto others by marriage are both constitutive ofhuman society. Human community is based in part on the fact that there are limitations as to what each of us as individual knowers can know. We need each other's knowledge. If one of us were per impossibile to transcend the limitations of human knowledge, he would know, as it were, what God knows and thus have the power that God has. But the existence of these limitations reveals something deep about human knowledge, something which traditional theory of knowledge rejects, namely that it is human. Human knowledge is limited, but it is genuine. It rests on no surer a foundation than human community, but human beings are a community. We need each other, but we are there for each other. Community, and therefore knowledge, does not need to be achieved: it exists.4 Similarly, the conventions in society limiting the capacity to relate oneselfto others by marriage (one at a time, and only under protest not one forever) reveal something deep about the nature of marriage. The mutuality of the intimacy ofmarriage is possible only in conjunction with the exclusiveness of marriage. Only by turning away from all others can the taking into... (shrink)